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- accession：NM_198336
- 基因别名：INSIG1
- 基因描述：Homo sapiens insulin induced gene 1 (INSIG1), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：537
- 翻译后氨基酸长度：178
- TranscriptVariant：This variant (2) uses an alternate in-frame splice site in the 5' coding region, and includes an alternate exon in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
- 基因简介：Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
