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- accession：NM_001270530
- 基因别名：RNF111
- 基因描述：Homo sapiens ring finger protein 111 (RNF111), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：2985
- 翻译后氨基酸长度：994
- TranscriptVariant：This variant (4) has multiple differences in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 4), compared to isoform 1.
- 基因简介：The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
