• 靶点-Target： ALS2
• MW(Observed)： 182kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;ELISA 1:5000-20000
• 组成： PBS， 50% glycerol， 0.05% Proclin 300， 0.05%BSA
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized peptide derived from human protein . at AA range: 390-470
• 特异性： ALS2 Polyclonal Antibody detects endogenous levels of protein.
• 基因名称： ALS2 ALS2CR6 KIAA1563
• 蛋白名称： Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein)
• Organism-1： Human
• 基因ID-1： 57679
• SwissProt-1： Q96Q42
• Organism-2： Mouse
• SwissProt-2： Q920R0
• Organism-3： Rat
• SwissProt-3： P0C5Y8
• 背景： The protein encoded by this gene contains an ATS1/RCC1-like domain， a RhoGEF domain， and a vacuolar protein sorting 9 (VPS9) domain， all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments， and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Oct 2008]，
• 细胞定位： ruffle，early endosome，centrosome，cytosol，postsynaptic density，membrane，lamellipodium，axon，dendrite，growth cone，vesicle，neuronal cell body，dendritic spine，intracellular membra

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