• 靶点-Target： PER1
• MW(Observed)： 141kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;ELISA 1:5000-20000
• 组成： PBS， 50% glycerol， 0.05% Proclin 300， 0.05%BSA
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized peptide derived from human protein . at AA range: 1110-1190
• 特异性： PER1 Polyclonal Antibody detects endogenous levels of protein.
• 基因名称： PER1 KIAA0482 PER RIGUI
• 蛋白名称： Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
• Organism-1： Human
• 基因ID-1： 5187
• SwissProt-1： O15534
• Organism-2： Mouse
• SwissProt-2： O35973
• Organism-3： Rat
• SwissProt-3： Q8CHI5
• 背景： This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus， the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity， metabolism， and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however， these variants have not been fully described. [provided by RefSeq， Jan 2014]，
• 细胞定位： Nucleus. Cytoplasm. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2 (By similarity). .

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