• 靶点-Target： SRBP2
• MW(Observed)： 125kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;ELISA 1:5000-20000
• 组成： PBS， 50% glycerol， 0.05% Proclin 300， 0.05%BSA
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized peptide derived from human protein . at AA range: 390-470
• 特异性： SRBP2 Polyclonal Antibody detects endogenous levels of protein.
• 基因名称： SREBF2 BHLHD2 SREBP2
• 蛋白名称： Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2]
• Organism-1： Human
• 基因ID-1： 6721
• SwissProt-1： Q12772
• Organism-2： Mouse
• SwissProt-2： Q3U1N2
• Organism-3： Rat
• SwissProt-3： Q3T1I5
• 背景： This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq， Jul 2013]，
• 细胞定位： [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle， COPII-coated vesicle membrane ; Multi-pass membrane protein . At high sterol concentrations， the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi， where it is processed (PubMed:32322062). .; [Processed sterol regulatory element-binding protein 2]: Nucleus . Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. .

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