• 靶点-Target： E2F-1
• MW(Observed)： 60kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500;ICC 1:100;IF 1:50-200
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human E2F-1 protein fragments expressed in E.coli.
• 特异性： This antibody detects endogenous levels of E2F-1 and does not cross-react with related proteins.
• 基因名称： e2f1
• Organism-1： Human
• 基因ID-1： 1869
• SwissProt-1： Q01094
• Organism-2： Mouse
• SwissProt-2： Q61501
• 背景： The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain， a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP)， a transactivation domain enriched in acidic amino acids， and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members， E2F2 and E2F3， have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media
• 细胞定位： Nucleus .

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