• 靶点-Target： SIRT6
• MW(Observed)： 42kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500;IF/ICC1:100
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human SIRT6 protein expressed in E.coli.
• 特异性： This antibody detects endogenous levels of SIRT6 and does not cross-react with related proteins.
• 基因名称： sirt6
• Organism-1： Human
• 基因ID-1： 51548
• SwissProt-1： Q8N6T7
• Organism-2： Mouse
• SwissProt-2： P59941
• 背景： This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance， genomic stability， aging and energy homeostasis. The encoded protein is localized to the nucleus， exhibits ADP-ribosyl transferase and histone deacetylase activities， and plays a role in DNA repair， maintenance of telomeric chromatin， inflammation， lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq， Mar 2016]，
• 细胞定位： Nucleus . Chromosome . Chromosome， telomere . Endoplasmic reticulum . Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721， PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843， PubMed:23911928， PubMed:27568560， PubMed:31995034， PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). .

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