• 靶点-Target： AMPKα1
• MW(Calculated)： 64kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： Affinity purification
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant fragment of human AMPKα1 expressed in E. Coli.
• 特异性： AMPKα1 Monoclonal Antibody detects endogenous levels of AMPKα1 protein.
• 基因名称： AAPK1
• 蛋白名称： 5‘-AMP-activated protein kinase catalytic subunit alpha-1
• Organism-1： Human
• 基因ID-1： 5562
• SwissProt-1： Q13131
• Organism-2： Mouse
• 基因ID-2： 105787
• SwissProt-2： Q5EG47
• Organism-3： Rat
• 基因ID-3： 65248
• SwissProt-3： P54645
• 背景： The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq， Jul 2008]，
• 细胞定位： Cytoplasm . Nucleus . In response to stress， recruited by p53/TP53 to specific promoters. .

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