• 靶点-Target： Caspase-9
• MW(Observed)： 35kD，46kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;IHC 1:50-300;IF 1:50-300
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human Caspase 9. AA range:266-315
• 特异性： Cleaved-Caspase-9 p35 (D315) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-9 p35 protein resulting from cleavage adjacent to D315.
• 基因名称： CASP9
• 蛋白名称： Caspase9
• Organism-1： Human
• 基因ID-1： 842
• SwissProt-1： P55211
• 背景： CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits， large and small， that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome， a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
• 细胞定位： nucleus，mitochondrion，cytosol，apoptosome，

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