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- accession：NM_001204870
- 基因别名：CCN4; WISP1c; WISP1i; WISP1tc
- 基因描述：Homo sapiens WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：369
- 翻译后氨基酸长度：122
- TranscriptVariant：This variant (4) lacks three internal exons in the coding region, as compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, as compared to isoform 1.
- 基因简介：This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
