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人 MDC1 (NM_014641) cDNA克隆
人 MDC1 (NM_014641) cDNA克隆
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  • 商品货号:G167790
  • accession:NM_014641
  • 基因别名:NFBD1
  • 基因描述:Homo sapiens mediator of DNA-damage checkpoint 1 (MDC1), mRNA.
  • 载体:现货载体
  • CDS区长度:6270
  • 翻译后氨基酸长度:2089
  • 基因简介:The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
  • 规格:10ul 质粒
CDS区参考序列: 点击查看序列
翻译后氨基酸参数序列: 点击查看序列