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人 CR1 (NM_000651) cDNA克隆
人 CR1 (NM_000651) cDNA克隆
  • 商品货号:FC172696
  • 已售 3 件 | 评价 0 人次 | 关注度 946
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    • accession:NM_000651
    • 基因别名:CR1
    • 基因描述:Homo sapiens complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant S, mRNA.
    • 载体:现货载体
    • CDS区长度:7470
    • 翻译后氨基酸长度:2489
    • TranscriptVariant:This variant (S, also referred to as B) represents the longer transcript and encodes the longer isoform (S, also referred to as isoform CR1-B or CR1*2).
    • 基因简介:This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
    • 规格:10ul 质粒
    CDS区参考序列: 点击查看序列
    翻译后氨基酸参数序列: 点击查看序列