• accession：NM_018319
• 基因别名：TDP1
• 基因描述：Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
• 载体： 现货载体
• CDS区长度：1827
• 翻译后氨基酸长度：608
• TranscriptVariant：This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
• 基因简介：The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008]
• 载体信息：自有图片地址
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGTCTCAGGAAGGCGATTATGGGAGGTGGACCATATCTAGTAGTGATGAAAGTGAGGAAGAAAAGCCAAAACCAGACAAGCCATCTACCTCTTCTCTTCTCTGTGCCAGGCAAGGAGCAGCAAATGAGCCCAGGTACACCTGTTCCGAGGCCCAGAAAGCTGCACACAAGAGGAAAATATCACCTGTGAAATTCAGCAATACAGATTCAGTTTTACCTCCCAAAAGGCAGAAAAGCGGTTCCCAGGAGGACCTCGGCTGGTGTCTGTCCAGCAGTGATGATGAGCTGCAACCAGAAATGCCGCAGAAGCAGGCTGAGAAAGTGGTGATCAAAAAGGAGAAAGACATCTCTGCTCCCAATGACGGCACTGCCCAAAGAACTGAAAATCATGGCGCTCCCGCCTGCCACAGGCTCAAAGAGGAGGAAGACGAGTATGAGACATCAGGGGAGGGCCAGGACATTTGGGACATGCTGGATAAAGGGAACCCCTTCCAGTTTTACCTCACTAGAGTCTCTGGAGTTAAGCCAAAGTATAACTCTGGAGCCCTCCACATCAAGGATATTTTATCTCCTTTATTTGGGACGCTTGTTTCTTCAGCTCAGTTTAACTACTGCTTTGACGTGGACTGGCTCGTAAAACAGTATCCACCAGAGTTCAGGAAGAAGCCAATCCTGCTTGTGCATGGTGATAAGCGAGAGGCTAAGGCTCACCTCCATGCCCAGGCCAAGCCTTACGAGAACATCTCTCTCTGCCAGGCAAAGTTGGATATTGCGTTTGGAACACACCACACGAAAATGATGCTGCTGCTCTATGAAGAAGGCCTCCGGGTTGTCATACACACCTCCAACCTCATCCATGCTGACTGGCACCAGAAAACTCAAGGAATATGGTTGAGCCCCTTATACCCACGAATTGCTGATGGAACCCACAAATCTGGAGAGTCGCCAACACATTTTAAAGCTGATCTCATCAGTTACTTGATGGCTTATAATGCCCCTTCTCTCAAGGAGTGGATAGATGTCATTCACAAGCACGATCTCTCTGAAACAAATGTTTATCTTATTGGTTCAACCCCAGGACGCTTTCAAGGAAGTCAAAAAGATAATTGGGGACATTTTAGACTTAAGAAGCTTCTGAAAGACCATGCCTCATCCATGCCTAACGCAGAGTCCTGGCCTGTCGTAGGTCAGTTTTCAAGCGTTGGCTCCTTGGGAGCCGATGAATCAAAGTGGTTATGTTCTGAGTTTAAAGAGAGCATGCTGACACTGGGGAAGGAAAGCAAGACTCCAGGAAAAAGCTCTGTTCCTCTTTACTTGATCTATCCTTCTGTGGAAAATGTGCGGACCAGTTTAGAAGGATATCCTGCTGGGGGCTCTCTTCCCTATAGCATCCAGACAGCTGAAAAACAGAATTGGCTGCATTCCTATTTTCACAAATGGTCAGCTGAGACTTCTGGCCGCAGCAATGCCATGCCACATATTAAGACATATATGAGGCCTTCTCCAGACTTCAGTAAAATTGCTTGGTTCCTTGTCACAAGCGCAAATCTGTCCAAGGCTGCCTGGGGAGCATTGGAGAAGAATGGCACCCAGCTGATGATCCGCTCCTACGAGCTCGGGGTCCTTTTCCTCCCTTCAGCATTTGGTCTAGACAGTTTCAAAGTGAAACAGAAGTTCTTCGCTGGCAGCCAGGAGCCAATGGCCACCTTTCCTGTGCCATATGATTTGCCTCCAGAACTGTATGGAAGTAAAGATCGGCCATGGATATGGAACATTCCTTATGTCAAAGCACCGGATACGCATGGGAACATGTGGGTGCCCTCCTGA

翻译后氨基酸参数序列： 点击查看序列

ATGTCTCAGGAAGGCGATTATGGGAGGTGGACCATATCTAGTAGTGATGAAAGTGAGGAAGAAAAGCCAAAACCAGACAAGCCATCTACCTCTTCTCTTCTCTGTGCCAGGCAAGGAGCAGCAAATGAGCCCAGGTACACCTGTTCCGAGGCCCAGAAAGCTGCACACAAGAGGAAAATATCACCTGTGAAATTCAGCAATACAGATTCAGTTTTACCTCCCAAAAGGCAGAAAAGCGGTTCCCAGGAGGACCTCGGCTGGTGTCTGTCCAGCAGTGATGATGAGCTGCAACCAGAAATGCCGCAGAAGCAGGCTGAGAAAGTGGTGATCAAAAAGGAGAAAGACATCTCTGCTCCCAATGACGGCACTGCCCAAAGAACTGAAAATCATGGCGCTCCCGCCTGCCACAGGCTCAAAGAGGAGGAAGACGAGTATGAGACATCAGGGGAGGGCCAGGACATTTGGGACATGCTGGATAAAGGGAACCCCTTCCAGTTTTACCTCACTAGAGTCTCTGGAGTTAAGCCAAAGTATAACTCTGGAGCCCTCCACATCAAGGATATTTTATCTCCTTTATTTGGGACGCTTGTTTCTTCAGCTCAGTTTAACTACTGCTTTGACGTGGACTGGCTCGTAAAACAGTATCCACCAGAGTTCAGGAAGAAGCCAATCCTGCTTGTGCATGGTGATAAGCGAGAGGCTAAGGCTCACCTCCATGCCCAGGCCAAGCCTTACGAGAACATCTCTCTCTGCCAGGCAAAGTTGGATATTGCGTTTGGAACACACCACACGAAAATGATGCTGCTGCTCTATGAAGAAGGCCTCCGGGTTGTCATACACACCTCCAACCTCATCCATGCTGACTGGCACCAGAAAACTCAAGGAATATGGTTGAGCCCCTTATACCCACGAATTGCTGATGGAACCCACAAATCTGGAGAGTCGCCAACACATTTTAAAGCTGATCTCATCAGTTACTTGATGGCTTATAATGCCCCTTCTCTCAAGGAGTGGATAGATGTCATTCACAAGCACGATCTCTCTGAAACAAATGTTTATCTTATTGGTTCAACCCCAGGACGCTTTCAAGGAAGTCAAAAAGATAATTGGGGACATTTTAGACTTAAGAAGCTTCTGAAAGACCATGCCTCATCCATGCCTAACGCAGAGTCCTGGCCTGTCGTAGGTCAGTTTTCAAGCGTTGGCTCCTTGGGAGCCGATGAATCAAAGTGGTTATGTTCTGAGTTTAAAGAGAGCATGCTGACACTGGGGAAGGAAAGCAAGACTCCAGGAAAAAGCTCTGTTCCTCTTTACTTGATCTATCCTTCTGTGGAAAATGTGCGGACCAGTTTAGAAGGATATCCTGCTGGGGGCTCTCTTCCCTATAGCATCCAGACAGCTGAAAAACAGAATTGGCTGCATTCCTATTTTCACAAATGGTCAGCTGAGACTTCTGGCCGCAGCAATGCCATGCCACATATTAAGACATATATGAGGCCTTCTCCAGACTTCAGTAAAATTGCTTGGTTCCTTGTCACAAGCGCAAATCTGTCCAAGGCTGCCTGGGGAGCATTGGAGAAGAATGGCACCCAGCTGATGATCCGCTCCTACGAGCTCGGGGTCCTTTTCCTCCCTTCAGCATTTGGTCTAGACAGTTTCAAAGTGAAACAGAAGTTCTTCGCTGGCAGCCAGGAGCCAATGGCCACCTTTCCTGTGCCATATGATTTGCCTCCAGAACTGTATGGAAGTAAAGATCGGCCATGGATATGGAACATTCCTTATGTCAAAGCACCGGATACGCATGGGAACATGTGGGTGCCCTCCTGA